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A new experimental platform facilitatesassessment of the transcriptional and chromatin landscapes of aging yeast

Authors: David G Hendrickson, Ilya Soifer, Bernd J Wranik, Griffin Kim, Michael Robles, Patrick A Gibney†, R Scott McIsaac* Replicative aging of Saccharomyces cerevisiae is an established model system…

Cell Biology, Confocal, iSIM, live cell imaging, super resolution

Transbilayer Movement of Sphingomyelin Precedes Catastrophic Breakage of Enterobacteria-Containing Vacuoles

Authors: Cara J. Ellison, Wanda Kukulski, Keith B. Boyle, Sean Munro, Felix Randow Pathogenic bacteria enter the cytosol of host cells through uptake into bacteria-containing vacuoles (BCVs) and subsequent rupture…

Cell Biology, Confocal, iSIM, live cell imaging, super resolution

Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria

Authors: Chung Yu Chana,b,1, Anthony M. Pedleyb,1, Doory Kimc,1,2, Chenglong Xiac, Xiaowei Zhuangc,d,e,3, and Stephen J. Benkovicb,3 To meet their purine demand, cells activate the de novo purine biosynthetic pathway…

Cell Biology, Confocal, iSIM, live cell imaging, super resolution, VisiTech

Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments

Authors: Erdem D. Tabdanov 1,2,3#, Nelson J. Rodríguez-Merced 1,2, Alexander X. Cartagena-Rivera 4, Vikram V. Puram 1,2,5, Mackenzie K. Callaway 1,2, Ethan A. Ensminger 1,2, Emily J. Pomeroy 6,7,8, Kenta…

Cell Biology, Confocal, iSIM, live cell imaging, super resolution, VisiTech

Mimicry embedding for advanced neural network training of 3D biomedical micrographs

Authors: Artur Yakimovich, Moona Huttunen, Jerzy Samolej, Barbara Clough, Nagisa Yoshida, Serge Mostowy, Eva Frickel, and Jason Mercer The use of deep neural networks (DNNs) for analysis of complex biomedical…

Cell Biology, Confocal, iSIM, live cell imaging, VisiTech

FMNL2 regulates dynamics of fascin in filopodia

Authors: Karin Pfisterer, James Levitt, Campbell D. Lawson, Richard J. Marsh1, John M. Heddleston, Eric Wait, Simon Morris Ameer-Beg, Susan Cox, and Maddy Parsons Filopodia are peripheral F-actin–rich structures that…

Cell Biology, Confocal, iSIM, live cell imaging, super resolution, VisiTech

Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress

Authors: Moona Huttunen, Artur Yakimovich, Ian J. White, Janos Kriston-Vizi, Juan Martin-Serrano, Wesley I. Sundquist, Jason Mercer Unlike most enveloped viruses, poxvirus egress is a complex process whereby cytoplasmic single membrane-bound virions are wrapped in a cell-derived double membrane. These triple membrane-bound particles,…

Cell Biology, Confocal, iSIM, super resolution, VisiTech

Results

A new experimental platform facilitatesassessment of the transcriptional and chromatin landscapes of aging yeast

Transbilayer Movement of Sphingomyelin Precedes Catastrophic Breakage of Enterobacteria-Containing Vacuoles

Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria

Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments

Mimicry embedding for advanced neural network training of 3D biomedical micrographs

FMNL2 regulates dynamics of fascin in filopodia

Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress

Small Molecule Enhancers of Endosome-to-Cytosol Import Augment Anti-tumor Immunity

Actin cables and comet tails organize mitochondrial networks in mitosis

Mechanosensitive Expression of Lamellipodin Governs Cell Cycle Progression and Intracellular Stiffness

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