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Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria

Authors: Chung Yu Chana,b,1, Anthony M. Pedleyb,1, Doory Kimc,1,2, Chenglong Xiac, Xiaowei Zhuangc,d,e,3, and Stephen J. Benkovicb,3 To meet their purine demand, cells activate the de novo purine biosynthetic pathway…

Cell Biology, Confocal, iSIM, live cell imaging, super resolution, VisiTech

Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions

Authors: Daan Vorselen1,2, Yifan Wang3, Miguel M. de Jesus 4, Pavak K. Shah5, Matthew J. Footer1,2, Morgan Huse4, Wei Cai 3 & Julie A. Theriot 1,2* Force exertion is an…

Confocal, Developmental Biology, iSIM, live cell imaging, super resolution, VisiTech, VTi

Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments

Authors: Erdem D. Tabdanov 1,2,3#, Nelson J. Rodríguez-Merced 1,2, Alexander X. Cartagena-Rivera 4, Vikram V. Puram 1,2,5, Mackenzie K. Callaway 1,2, Ethan A. Ensminger 1,2, Emily J. Pomeroy 6,7,8, Kenta…

Cell Biology, Confocal, iSIM, live cell imaging, super resolution, VisiTech

Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis

Authors: Edgar-John Vogt, Keizo Tokuhiro, Min Guo, Ryan Dale, Guanghui Yang, Seung-Wook Shin, Maria Jimenez Movilla, Hari Shroff & Jurrien Dean Following fertilization, cortical granules exocytose ovastacin, a metalloendopeptidase that…

Confocal, Developmental Biology, iSIM, live cell imaging, super resolution, VisiTech, VTi

Mimicry embedding for advanced neural network training of 3D biomedical micrographs

Authors: Artur Yakimovich, Moona Huttunen, Jerzy Samolej, Barbara Clough, Nagisa Yoshida, Serge Mostowy, Eva Frickel, and Jason Mercer The use of deep neural networks (DNNs) for analysis of complex biomedical…

Cell Biology, Confocal, iSIM, live cell imaging, VisiTech

Antimicrobial peptides against drug resistant Mycobacterium abscessus

Authors: Joas L. da Silva a, Shashank Gupta a, Kenneth N. Olivier a, *, 1, Adrian M. Zelazny b, 1 Mycobacterium abscessus (MAB) comprise rapidly growing, often multidrug-resistant (MDR), nontuberculous…

Confocal, Developmental Biology, iSIM, live cell imaging, super resolution, VisiTech, VTi

FMNL2 regulates dynamics of fascin in filopodia

Authors: Karin Pfisterer, James Levitt, Campbell D. Lawson, Richard J. Marsh1, John M. Heddleston, Eric Wait, Simon Morris Ameer-Beg, Susan Cox, and Maddy Parsons Filopodia are peripheral F-actin–rich structures that…

Cell Biology, Confocal, iSIM, live cell imaging, super resolution, VisiTech

Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress

Authors: Moona Huttunen, Artur Yakimovich, Ian J. White, Janos Kriston-Vizi, Juan Martin-Serrano, Wesley I. Sundquist, Jason Mercer Unlike most enveloped viruses, poxvirus egress is a complex process whereby cytoplasmic single membrane-bound virions are wrapped in a cell-derived double membrane. These triple membrane-bound particles,…

Cell Biology, Confocal, iSIM, super resolution, VisiTech

Small Molecule Enhancers of Endosome-to-Cytosol Import Augment Anti-tumor Immunity

Authors: Patrycja Kozik, Marine Gros, Daniel N. Itzhak, …, Elaine Del Nery, Georg H.H. Borner, Sebastian Amigorena Cross-presentation of antigens by dendritic cells (DCs) is critical for initiation of anti-tumor…

Cell Biology, Confocal, iSIM, live cell imaging, super resolution, VisiTech

Viscoelastic cluster densification in sheared colloidal gels

Authors: Roberta Massaro,a Gabriele Colombo,b Peter Van Puyveldea and Jan Vermant Many biological materials, consumer products and industrial formulations are colloidal suspensions where the suspending medium is itself a complex…

Colloidal Dynamics, Confocal, iSIM, super resolution, VisiTech, VTi

Results

Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria

Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions

Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments

Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis

Mimicry embedding for advanced neural network training of 3D biomedical micrographs

Antimicrobial peptides against drug resistant Mycobacterium abscessus

FMNL2 regulates dynamics of fascin in filopodia

Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress

Small Molecule Enhancers of Endosome-to-Cytosol Import Augment Anti-tumor Immunity

Viscoelastic cluster densification in sheared colloidal gels

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